A widely accepted measure of beta-cell function is the disposition index (DI), that is, the product of insulin sensitivity and insulin secretion 15. ![]() As the normal physiological response to decreased insulin sensitivity is an increase in insulin secretion, the assessment of beta-cell function should incorporate both measures (that is, insulin sensitivity and secretion) 15. The inconsistencies could also be related to a failure to correct for prevailing insulin sensitivity when assessing beta-cell function. ![]() Inconsistent findings may relate to differences in concomitant pharmacological therapy, the participants’ pretrial insulin secretory capacity, or differences in exercise modality, intensity and/or volume 10, 11, 12, 13, 14. Overall, adding an exercise intervention to diet-induced weight loss improves glucose-stimulated beta-cell function in people with newly diagnosed T2D in an exercise dose-dependent manner (NCT03769883).Īs the progressive deterioration of normal beta-cell function is regarded as a determining factor for the onset and subsequent progression of T2D, re-establishing beta-cell function is considered pivotal to improving the pathogenesis of T2D 1.Īlthough a substantial diet-induced weight loss is consistent with improved beta-cell function 2, 3, 4, the effects of exercise on beta-cell function in T2D are not well understood 5, 6, 7, 8, 9. We report three serious adverse events (two in the control group and one in the diet control group), as well as adverse events in two participants in the diet control group, and five participants each in the moderate and high exercise dose groups. Here, we carried out a four-armed randomized trial with a total of 82 persons (35% females, mean age (s.d.) of 58.2 years (9.8)) with newly diagnosed T2D ( 0.001 for trend). It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context.
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